CI-994 (Tacedinaline) is a potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
CI-994 show no significant inhibitory activity against HDAC8 (IC50>20 uM).
CI-994 reduces S phase level and increases apoptosis in A-549 and LX-1 cells.
CI-994 demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.
Physicochemical Properties
M.Wt
269.2985
Formula
C15H15N3O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 58 mg/mL
Chemical Name/SMILES
Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
References
1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
