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Chemical Structure : CI-994
CAS No.: 112522-64-2
Catalog No.: PC-45907Not For Human Use, Lab Use Only.
CI-994 (Tacedinaline) is a potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 25 mg | $78 | In stock | |
| 50 mg | $128 | In stock | |
| 100 mg | $198 | In stock | |
| 250 mg | $348 | In stock | |
| 1 g | Get quote |
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CI-994 (Tacedinaline) is a potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
CI-994 show no significant inhibitory activity against HDAC8 (IC50>20 uM).
CI-994 reduces S phase level and increases apoptosis in A-549 and LX-1 cells.
CI-994 demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.
| M.Wt | 269.2985 | |
| Formula | C15H15N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 58 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-(acetylamino)-N-(2-aminophenyl)- |
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1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
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