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Chemical Structure : CID661578
Catalog No.: PC-38906Not For Human Use, Lab Use Only.
CID661578 is a potent inducer of β-cell regeneration, targets MAP kinase-interacting serine/threonine kinase 2 (MNK2).
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CID661578 is a potent inducer of β-cell regeneration, targets MAP kinase-interacting serine/threonine kinase 2 (MNK2).
CID661578 increased β-cell neogenesis from ductal cells in zebrafish, neonatal pig islet aggregates and human pancreatic ductal organoids.
CID661578 boosts protein synthesis and regeneration by blocking MNK2 from binding eIF4G in the translation initiation complex at the mRNA cap.
| M.Wt | 356.353 | |
| Formula | C19H17FN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Karampelias C, et al. Nat Chem Biol. 2022 Jun 13. doi: 10.1038/s41589-022-01047-x.
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