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Chemical Structure : CID755673
CAS No.: 521937-07-5
Catalog No.: PC-42927Not For Human Use, Lab Use Only.
The first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CID755673 is the first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.
CID755673 exhibits selectivity for PKD1 versus AKT, PLK1, CAK, CAMKIIα and three PKC isoforms.
CID755673 blockes phorbol ester-induced endogenous PKD1 activation in LNCaP cells and inhibits prostate cancer cell proliferation, cell migration and invasion.
| M.Wt | 217.2206 | |
| Formula | C12H11NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
1H-Benzofuro[2,3-c]azepin-1-one, 2,3,4,5-tetrahydro-7-hydroxy- |
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1. Sharlow ER, et al. J Biol Chem. 2008 Nov 28;283(48):33516-26.
2. Torres-Marquez E, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):63-8.
3. Pilankatta R, et al. J Biol Chem. 2011 Mar 4;286(9):7389-96.
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