You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-PKD-CID755673
CID755673

Chemical Structure : CID755673

CAS No.: 521937-07-5

CID755673 (CID 755673;CID-755673)

Catalog No.: PC-42927Not For Human Use, Lab Use Only.

The first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.

Packing Price Stock Quantity
10 mg $88 In stock
25 mg $148 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CID755673 is the first potent and selective cell-active pan-PKD inhibitor with IC50s of 182/280/227 nM for PKD1/2/3 respectively.
CID755673 exhibits selectivity for PKD1 versus AKT, PLK1, CAK, CAMKIIα and three PKC isoforms.
CID755673 blockes phorbol ester-induced endogenous PKD1 activation in LNCaP cells and inhibits prostate cancer cell proliferation, cell migration and invasion.

Physicochemical Properties

M.Wt 217.2206
Formula C12H11NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 40 mg/mL

Chemical Name/SMILES

1H-Benzofuro[2,3-c]azepin-1-one, 2,3,4,5-tetrahydro-7-hydroxy-

References

1. Sharlow ER, et al. J Biol Chem. 2008 Nov 28;283(48):33516-26.

2. Torres-Marquez E, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):63-8.

3. Pilankatta R, et al. J Biol Chem. 2011 Mar 4;286(9):7389-96.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: