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Chemical Structure : CITCO
CAS No.: 338404-52-7
Catalog No.: PC-49715Not For Human Use, Lab Use Only.
CITCO is a potent, selective agonist of orphan nuclear constitutive androstane receptor (CAR) with EC50 of 49 nM (human CAR) in CAR/SRC-1 FRET assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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CITCO is a potent, selective agonist of orphan nuclear constitutive androstane receptor (CAR) with EC50 of 49 nM (human CAR) in CAR/SRC-1 FRET assays.
CITCO displayed calculated EC50 values of 25 nm in the CAR transient transfection assay, >100-fold selectivity over PXR, did not have any detectable activity on a panel of 15 nuclear receptors.
CITCO promotes nuclear translocation of humanCAR.
CITCO shows robust effects on CAR target genes CYP2B expression in mouse versushuman cells.
| M.Wt | 436.74 | |
| Formula | C19H12Cl3N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime |
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1. Maglich JM, et al. J Biol Chem. 2003 May 9;278(19):17277-83.
2. Jinno H, et al. Mol Pharmacol. 2004 Mar;65(3):496-502.
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