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CK-636

Chemical Structure : CK-636

CAS No.: 442632-72-6

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CK-636 (CK636, CK-0944636, CK0944636)

Catalog No.: PC-44784Not For Human Use, Lab Use Only.

CK-636 (CK-0944636) is a small molecule Arp2/3 complex inhibitor that inhibits actin polymerization stimulated by fission yeast Arp2/3 complex (SpArp2/3 complex, IC50 = 24 uM).

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10 mg $58 In stock
25 mg $98 In stock
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100 mg $238 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CK-636 (CK-0944636) is a small molecule Arp2/3 complex inhibitor that inhibits actin polymerization stimulated by fission yeast Arp2/3 complex (SpArp2/3 complex, IC50 = 24 uM).
CK-636 inhibits formation of actin filament comet tails by Listeria and podosomes by monocytes.

Physicochemical Properties

M.Wt 284.376
Formula C16H16N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 49 mg/mL
Chemical Name/SMILES

2-Thiophenecarboxamide, N-[2-(2-methyl-1H-indol-3-yl)ethyl]-

References

1. Nolen BJ, et al. Nature. 2009 Aug 20;460(7258):1031-4.

2. Zhou K, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9.

3. Weeks HP, et al. Anticancer Res. 2016 Mar;36(3):1135-42.

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