CK1γ inhibitor 1h

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Chemical Structure : CK1γ inhibitor 1h

Catalog No.: PC-25590Not For Human Use, Lab Use Only.

CK1γ inhibitor 1h is a potent, selective inhibitor of casein kinase 1γ (CK1γ) with IC50 of 18 nM, has >100-fold selective over CK1α, CK1δ and GSK3β, inhibits phosphorylation of LRP6 in HEK293 cell with IC50 of 0.7 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	292.34
Formula	C17H16N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(2-hydroxypropan-2-yl)phenyl)amino)-1H-benzo[d]imidazole-6-carbonitrile

References

1. Hua Z, et al. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5392-5.

2. Capener JL, et al. bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675406.

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