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CK2 bivalent inhibitor Biv5

Chemical Structure : CK2 bivalent inhibitor Biv5

CAS No.:

CK2 bivalent inhibitor Biv5

Catalog No.: PC-24756Not For Human Use, Lab Use Only.

CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells.
Biv5 demonstrated high potency, reducing intracellular viral RNA production by approximately three logs at 20 μM.
Biv5 inhibited SARS-CoV-2 infection in HEK-ACE2-TMPRSS2 cells, as evidenced by decreased nucleoprotein detection.
Biv5 dose-dependently reduced OC43 RNA production in HRT18 cells.
Biv5 exhibited excellent selectivity against 18 known CX-4945 targets.

Physicochemical Properties

M.Wt 567.13
Formula C34H35ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((8-(((2-chloro-[1,1′-biphenyl]-4-yl)methyl)amino)octyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid

References

1. Grenier D, et al. Eur J Med Chem. 2025 May 29;296:117826.

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