Chemical Structure : CK2 bivalent inhibitor Biv5
CAS No.:
CK2 bivalent inhibitor Biv5
Catalog No.: PC-24756Not For Human Use, Lab Use Only.
CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CK2 bivalent inhibitor Biv5 is a picomolar bivalent inhibitor of protein casein kinase 2 (CK2) with IC50 of 51 pM (CK2α), shows potent antiviral activity against SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells.
Biv5 demonstrated high potency, reducing intracellular viral RNA production by approximately three logs at 20 μM.
Biv5 inhibited SARS-CoV-2 infection in HEK-ACE2-TMPRSS2 cells, as evidenced by decreased nucleoprotein detection.
Biv5 dose-dependently reduced OC43 RNA production in HRT18 cells.
Biv5 exhibited excellent selectivity against 18 known CX-4945 targets.
Physicochemical Properties
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M.Wt
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567.13
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Formula
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C34H35ClN4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-((8-(((2-chloro-[1,1′-biphenyl]-4-yl)methyl)amino)octyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid
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References
1. Grenier D, et al. Eur J Med Chem. 2025 May 29;296:117826.
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