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Chemical Structure : CK2 inhibitor D11
Catalog No.: PC-60577Not For Human Use, Lab Use Only.
CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.
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CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.
D11 potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM).
D11 inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.
| M.Wt | 402.227 | |
| Formula | C20H13Cl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guerra B, et al. Mol Cell Biochem. 2015 Aug;406(1-2):151-61.
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