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CK2 inhibitor D11

Chemical Structure : CK2 inhibitor D11

CAS No.: 1803427-24-8

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CK2 inhibitor D11 (D11)

Catalog No.: PC-60577Not For Human Use, Lab Use Only.

CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CK2 inhibitor D11 is a potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM.
    D11 potently inhibits CK2α with IC50 of 7 nM, shows <2% remaining kinase activity against a panel of 354 eukaryotic protein kinases with exception of DYRK1B, PIM3 and IRAK1 (IC50=20-50 nM).
    D11 inhibits the phosphorylation of the CK2 biomarker CDC37 at S13 in MIA PaCa-2 cells, also inhibits S380/T382/383 phosphorylation in PTEN in NSCLC cells.

    Physicochemical Properties

    M.Wt 402.227
    Formula C20H13Cl2NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,3-Dichloro-6-[(E)-((4-methoxyphenyl)imino)methyl] dibenzo(b,d) furan-2,7-diol

    References

    1. Guerra B, et al. Mol Cell Biochem. 2015 Aug;406(1-2):151-61.

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