CL 316243 |CAS:183720-02-7 Probechem Biochemicals

Chemical Structure : CL 316243

CL 316243 (BTA 243)

Catalog No.: PC-62017Not For Human Use, Lab Use Only.

CL 316243 (BTA 243) is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.

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Biological Activity

CL 316243 (BTA 243) is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM.
CL 316243 displays >10000-fold selective over β1 and β2 receptors.
CL 316243 significantly increases brown adipose tissue thermogenesis and resting metabolic rate in mice, also increases the concentration of insulin receptors and decreases the levels of serum insulin and blood glucose during the glucose overloading test.

Physicochemical Properties

M.Wt	421.83
Formula	C20H20ClNO7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid

References

1. Berlan M, et al. J Pharmacol Exp Ther. 1994 Mar;268(3):1444-51.

2. Himms-Hagen J, et al. Am J Physiol. 1994 Apr;266(4 Pt 2):R1371-82.

3. Yoshida T, et al. Life Sci. 1994;54(7):491-8.

CL 316243 (BTA 243)

Biological Activity

Physicochemical Properties

References

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