Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CLC-2-IN-AK42
Catalog No.: PC-72552Not For Human Use, Lab Use Only.
CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).
AK42 displays unprecedented selectivity (>1,000-fold) over CLC-1, the closest CLC-2 homolog, and no off-target engagement a diverse panel of 61 CNS receptors, channels, and transporters expressed in brain tissue.
AK-42 binds to an extracellular vestibule above the channel pore.
AK-42 is almost three orders-of-magnitude more potent than MCFA, demonstrates high potency (IC50=14 nM for rat CLC-2) in manual patch-clamp experiments on CHO cells transiently transfected with rat CLC-2.
AK-42 inhibits hyperpolarization-activated current in hippocampal cells, attenuates steady-state currents and eliminated relaxation currents in recorded neurons.
AK-42 is a powerful tool for investigating CLC-2 neurophysiology.
| M.Wt | 389.232 | |
| Formula | C19H14Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Anna K Koster, et al. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32711-32721.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
