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Chemical Structure : CLP257
CAS No.: 1181081-71-9
Catalog No.: PC-60024Not For Human Use, Lab Use Only.
CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | Get quote |
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CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM.
CLP257 displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors.
CLP257 restores impaired Cl(-) transport in neurons, rescues KCC2 plasma membrane expression.
CLP257 renormalizes stimulus-evoked responses in spinal nociceptive pathways in a rat model of neuropathic pain.
| M.Wt | 307.34 | |
| Formula | C14H14FN3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
|
| Chemical Name/SMILES |
(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone |
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1. Cardarelli RA, et al. Nat Med. 2017 Dec 7;23(12):1394-1396.
2. Gagnon M, et al. Nat Med. 2013 Nov;19(11):1524-8.
3. Ferrini F, et al. Sci Rep. 2017 Jun 20;7(1):3870.
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