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Chemical Structure : CLP290
CAS No.: 1181083-81-7
Catalog No.: PC-35775Not For Human Use, Lab Use Only.
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257.
In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons.
Co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior.
| M.Wt | 404.46 | |
| Formula | C19H21FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine-1-carboxylate |
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1. Chen B, et al. Cell. 2018 Jul 26;174(3):521-535.e13.
2. Ferrini F, et al. Sci Rep. 2017 Jun 20;7(1):3870.
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