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CM-304

Chemical Structure : CM-304

CAS No.: 1350296-21-7

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CM-304 (CM304)

Catalog No.: PC-21110Not For Human Use, Lab Use Only.

CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R.
CM-304 also shows >10,000-fold selectivity over 59 other targets, including opioid and 5-HT receptors.
CM-304 demonstrated anti-allodynic effects in the CCI assay.
CM-304demonstrated dose-dependent antinociception following i.p. administration in the mouse acetic-acid writhing assay.

Physicochemical Properties

M.Wt 336.47
Formula C18H25FN2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-(azepan-1-yl)ethyl)-6-(3-fluoropropyl)benzo[d]thiazol-2(3H)-one

References

1. Cirino TJ, et al. Front Pharmacol. 2019 Jun 14;10:678.

2. James M. L, et al. J. Med. Chem. 55 (19), 8272–8282.

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