Chemical Structure : CM-398
CAS No.:
1121931-70-1
CM-398
(CM398)
Catalog No.: PC-21109Not For Human Use, Lab Use Only.
CM-398 (CM398) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 0.43 nM, >1000-fold selective over σ1R, produces antinociception and anti-allodynia effects.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CM-398 (CM398) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 0.43 nM, >1000-fold selective over σ1R, produces antinociception and anti-allodynia effects.
CM398 showed promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice.
CM-398 dose-dependently (10-45 mg/kg i.p.) reduced mechanical allodynia in the CCI neuropathic pain model, equivalent at the higher dose to the effect of the control analgesic gabapentin (50 mg/kg i.p.).
M-398 dose-dependently produced antinociception in the acetic acid writhing test (ED50 (and 95% C.I.) = 14.7 (10.6–20) mg/kg, i.p.) and the formalin assay (ED50 (and 95% C.I.) = 0.86 (0.44–1.81) mg/kg, i.p.) but was without effect in the 55 °C warm-water tail-withdrawal assay.
Physicochemical Properties
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M.Wt
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395.50
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Formula
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C23H29N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1h)-yl)butyl)-3-methyl-1h-benzo[d]imidazol-2(3H)-one
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References
1. Intagliata S., et al. AAPS J. 2020;22:94.
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