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CM-444

Chemical Structure : CM-444

CAS No.: 2256079-52-2

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CM-444 (CM444)

Catalog No.: PC-21608Not For Human Use, Lab Use Only.

CM-444 is a potent histone deacetylase (HDAC) inhibitor with IC50 of 7/51/18/531 nM for HDAC1/2/3/6 respectively, also inhibits DNMT1 with IC50 of 2160 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CM-444 is a potent histone deacetylase (HDAC) inhibitor with IC50 of 7/51/18/531 nM for HDAC1/2/3/6 respectively, also inhibits DNMT1 with IC50 of 2160 nM.
    CM-444 does not inhibit G9a (IC50>10 uM).
    CM-444 exhibits a potent antiproliferative response against the MM1.S cell line (GI50 = 32 nM).
    CM-444 also shows potent antiproliferative activity against other MM cell lines (JJN3, KMS28BM, and H929) with GI50 values between 100 and 550 nM.
    CM-444 (10 mg/kg, i.p.) shows in vivo efficacy in an MM1.S tumor model.

    Physicochemical Properties

    M.Wt 518.57
    Formula C27H30N6O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[4-[[[6,7-Dimethoxy-2-(5-methyl-2-furyl)-4-quinolyl]amino]methyl]-1-piperidyl]pyrimidine-5-carbohydroxamic Acid

    References

    1. Rabal O, et al. J Med Chem. 2021;64:3392–426.

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