Chemical Structure : CM11
CAS No.:
2244684-49-7
CM11
(homo-PROTAC CM11, VHL degrader CM11)
Catalog No. : PC-60127Not For Human Use, Lab Use Only.
CM11 is a homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6012701
Biological Activity
CM11 is a homo-PROTAC , bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce VHL self-degradation.
Physicochemical Properties
M.Wt
1179.456
Formula
C58H82N8O14S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N1,N20-bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
References
1. Maniaci C, et al. Nat Commun.
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