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CM572

Chemical Structure : CM572

CAS No.: 1121932-91-9

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CM572 (CM 572;CM-572)

Catalog No.: PC-60747Not For Human Use, Lab Use Only.

CM572 is a potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CM572 is a potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors.
    CM572 induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM.
    CM572 also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.

    Physicochemical Properties

    M.Wt 426.51
    Formula C22H23FN4O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)-6-isothiocyanatobenzo[d]oxazol-2(3H)-one

    References

    1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.

    2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43.

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