CM699

Chemical Structure : CM699

Catalog No.: PC-24306Not For Human Use, Lab Use Only.

CM699 isa dual-action compound with σ1R antagonist effects and affinity for the DAT with Ki of 311 and 14.1 nM at DAT and σ1Rs, respectively, inhibits DA uptake ex vivo.

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Biological Activity

CM699 isa dual-action compound with σ1R antagonist effects and affinity for the DAT with Ki of 311 and 14.1 nM at DAT and σ1Rs, respectively, inhibits DA uptake ex vivo.
CM699 displaced [3H]DTG with 2.31 nM affinity at the DTG high-affinity site.
CM699 blocked cocaine self-administration, indicating efficacy as a cocaine antagonist in vivo.

Physicochemical Properties

M.Wt	391.52
Formula	C24H29N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3H-spiro[isobenzofuran-1,4'-piperidin]-1'-yl)butyl)-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

References

1. Hiranita T, et al. ACS Chem Neurosci. 2025 Mar 25. doi: 10.1021/acschemneuro.4c00589.

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CM699

Biological Activity

Physicochemical Properties

References

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