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CM764

Chemical Structure : CM764

CAS No.: 1350296-29-5

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CM764 (C764;CM-764)

Catalog No.: PC-60750Not For Human Use, Lab Use Only.

CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CM764 is a potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM).
    CM764 increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation.
    CM764 increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.

    Physicochemical Properties

    M.Wt 426.492
    Formula C23H27FN4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-acetyl-3-(4-(4-(2-amino-4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one

    References

    1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43.

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