CMS121 is a small molecule fatty acid synthase (FASN) inhibitor, reduces lipid peroxidation and neuroinflammation both in vitro and in vivo. CMS121 is able to rescue cells from oxytotic/ferroptotic cell death. CMS121 decreases lipid peroxidation and has anti-inflammatory properties, modulates lipid metabolism. CMS121 alleviates cognitive loss, modulates lipid metabolism and reduces inflammation and lipid peroxidation in the brains of transgenic AD mice.
