Chemical Structure : CO-1686
CAS No.:
1374640-70-6
CO-1686
(Rociletinib, AVL-301, CNX-419)
Catalog No. : PC-44666Not For Human Use, Lab Use Only.
Rociletinib (CO1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4466601
Biological Activity
Rociletinib (CO1686, AVL-301, CNX-419) is a potent, highly selective, irreversible inhibitor of mutant EGFR with Ki of 21.5 nM for EGFR L858R/T790M .
Physicochemical Properties
M.Wt
555.5515
Formula
C27H28F3N7O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 43 mg/mL
Chemical Name/SMILES
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-
References
1. Walter AO, et al. Cancer Discov
2. Tjin Tham Sjin R, et al. Mol Cancer Ther
3. Sequist LV, et al. N Engl J Med
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