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Chemical Structure : COR388
Catalog No.: PC-72417Not For Human Use, Lab Use Only.
COR388 (Atuzaginstat) is an orally bioavailable, brain penetrant small-molecule that irreversibly inhibits lysine-gingipain (Kgp) with Ki of <0.01 nM.
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COR388 (Atuzaginstat) is an orally bioavailable, brain penetrant small-molecule that irreversibly inhibits lysine-gingipain (Kgp, gingipain K) with Ki of <0.01 nM.
COR388 blocks the activity of gingipains, a type of toxic protein made by the bacteria Porphyromonas gingivalis ( P. gingivalis ).
COR388 reduced the bacterial load of an established P. gingivalis brain infection, blocked Aβ1-42 production, reduced neuroinflammation, and rescued neurons in the hippocampus.
| M.Wt | 386.415 | |
| Formula | C19H25F3N2O3 | |
| Appearance | Solid | |
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1. Shirin Arastu-Kapur, et al. Pharmacol Res Perspect. 2020 Feb;8(1):e00562.
2. Stephen S Dominy, et al. Sci Adv. 2019 Jan 23;5(1):eaau3333.
3. Kenneth Barth, et al. Sci Rep. 2016 Oct 4;6:34656.
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