Catalog No.: PC-72608Not For Human Use, Lab Use Only.
CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP100356 did not block receptor binding at the cell surface, it inhibited low-pH-dependent membrane fusion mediated by arenavirus glycoproteins.
CP-100356 is an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat.
CP-100356 inhibited acetoxymethyl calcein (calcein-AM) uptake (IC50= 0.5 uM) and digoxin transport (IC50=1.2 uM) in human MDR1-transfected MDCKII cells.
