Chemical Structure : CP-100356 hydrochloride
CAS No.:
142715-48-8
CP-100356 hydrochloride
(CP100356)
Catalog No.: PC-72608Not For Human Use, Lab Use Only.
CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CP-100356 hydrochloride (CP100356) is a specific P-glycoprotein (P-gp) inhibitor, suppresses VSV-LASVGP, LCMV, and LASV infection with IC50 of 0.52, 0.54, and 0.062 uM, respectively, without significant cytotoxicity.
CP100356 did not block receptor binding at the cell surface, it inhibited low-pH-dependent membrane fusion mediated by arenavirus glycoproteins.
CP-100356 is an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat.
CP-100356 inhibited acetoxymethyl calcein (calcein-AM) uptake (IC50= 0.5 uM) and digoxin transport (IC50=1.2 uM) in human MDR1-transfected MDCKII cells.
Physicochemical Properties
|
M.Wt
|
597.109
|
|
Formula
|
C31H37ClN4O6
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-N-(3,4-dimethoxyphenethyl)-6,7-dimethoxyquinazolin-2-amine hydrochloride
|
References
1. Takenaga T, et al. Viruses. 2021 Sep 3;13(9):1763.
2. Kalgutkar AS, et al. J Pharm Sci. 2009 Dec;98(12):4914-27.
Contact Us
sales@probechem.com
