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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Microsomal Triglyceride Transfer Protein (MTP)-CP-346086
CP-346086

Chemical Structure : CP-346086

CAS No.: 186390-48-7

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CP-346086 (CP 346086;CP346086)

Catalog No.: PC-60675Not For Human Use, Lab Use Only.

A potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, orally active microsomal triglyceride transfer protein (MTP) inhibitor that inhibits both human and rodent MTP with IC50 of 2 nM; inhibits apolipoprotein B (apoB) and triglyceride secretion (IC50=2.6 nM) without affecting apoA-I secretion or lipid synthesis; lowers total, VLDL, and LDL cholesterol and triglycerides in rats.

Physicochemical Properties

M.Wt 477.491
Formula C26H22F3N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((1H-1,2,4-triazol-5-yl)methyl)-1,2,3,4-tetrahydroisoquinolin-6-yl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide

References

1. Chandler CE, et al. J Lipid Res. 2003 Oct;44(10):1887-901.

2. Lamant M, et al. J Biol Chem. 2006 Nov 24;281(47):36289-302.

3. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.

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