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Chemical Structure : CP134
Catalog No.: PC-22688Not For Human Use, Lab Use Only.
CP134 is a potent, selective PROTAC degrader of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with DC50 of 1.6 uM in MM231 and 3.3 uM in HeLa, respectively.
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CP134 is a potent, selective PROTAC degrader of dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) with DC50 of 1.6 uM in MM231 and 3.3 uM in HeLa, respectively.
CP134 reduced the intracellular DYRK2 level in a concentration- and time-dependent manner.
CP134 (5 uM) significantly downregulated the levels of phosphorylated p53 (Ser46) and c-Myc (Ser62) in MM231 cells.
CP134 effectively inhibited cell proliferation with IC50 values of 9.1 uM in MM231 cell line.
| M.Wt | 921.64 | |
| Formula | C42H43Br2N5O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen J, et al. ACS Med Chem Lett. 2024 Apr 30;15(5):659-666.
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