Chemical Structure : CP 376395
CAS No.:
175140-00-8
CP 376395
(CP376395, CP-376395)
Catalog No. : PC-61268Not For Human Use, Lab Use Only.
CP376395 is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6126801
Biological Activity
CP376395 is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
Physicochemical Properties
M.Wt
326.484
Formula
C21H30N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine
References
1. Chen YL, et al. J Med Chem.
2. Blacktop JM, et al. J Neurosci.
3. Simms JA, et al. Addict Biol.
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