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Chemical Structure : CP 376395
CAS No.: 175140-00-8
Catalog No.: PC-61268Not For Human Use, Lab Use Only.
CP376395 is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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CP376395 is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
CP376395 significantly attenuates activation of the HPA axis (MED=10 mg/kg, p.o), reverses the excitation of locus coeruleus neurons induced by CRF in CNS in vivo.
| M.Wt | 326.484 | |
| Formula | C21H30N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine |
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1. Chen YL, et al. J Med Chem. 2008 Mar 13;51(5):1385-92.
2. Blacktop JM, et al. J Neurosci. 2011 Aug 3;31(31):11396-403.
3. Simms JA, et al. Addict Biol. 2014 Jul;19(4):606-11.
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