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Chemical Structure : CP 376395 hydrochloride
Catalog No.: PC-61267Not For Human Use, Lab Use Only.
A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
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A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM); significantly attenuates activation of the HPA axis (MED=10 mg/kg, p.o), reverses the excitation of locus coeruleus neurons induced by CRF in CNS in vivo.
| M.Wt | 362.942 | |
| Formula | C21H31ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen YL, et al. J Med Chem. 2008 Mar 13;51(5):1385-92.
2. Blacktop JM, et al. J Neurosci. 2011 Aug 3;31(31):11396-403.
3. Simms JA, et al. Addict Biol. 2014 Jul;19(4):606-11.
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