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CP 376395 hydrochloride

Chemical Structure : CP 376395 hydrochloride

CAS No.: 1013933-37-3

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CP 376395 hydrochloride (CP376395, CP-376395)

Catalog No.: PC-61267Not For Human Use, Lab Use Only.

A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CP 376395 hydrochloride is a  potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
    CP 376395 significantly attenuates activation of the HPA axis (MED=10 mg/kg, p.o), reverses the excitation of locus coeruleus neurons induced by CRF in CNS in vivo.

    Physicochemical Properties

    M.Wt 362.942
    Formula C21H31ClN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(mesityloxy)-3,6-dimethyl-N-(pentan-3-yl)pyridin-4-amine hydrochloride

    References

    1. Chen YL, et al. J Med Chem. 2008 Mar 13;51(5):1385-92.

    2. Blacktop JM, et al. J Neurosci. 2011 Aug 3;31(31):11396-403.

    3. Simms JA, et al. Addict Biol. 2014 Jul;19(4):606-11.

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