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Chemical Structure : CPA7
Catalog No.: PC-60658Not For Human Use, Lab Use Only.
STAT3 inhibitor CPA7 is a platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.
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STAT3 inhibitor CPA7 is a platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.
CPA7 selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.
| M.Wt | 381.501 | |
| Formula | Cl3H6N3O2Pt | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42.
2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.
3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804.
4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504.
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