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CPAG-1

Chemical Structure : CPAG-1

CAS No.: 2094991-62-3

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CPAG-1 (PGRMC2 activator CPAG-1)

Catalog No.: PC-38286Not For Human Use, Lab Use Only.

CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CPAG-1 (PGRMC2 activator CPAG-1) is a small-molecule activator of PGRMC2.
    CPAG-1 treatment had no effect on weight or food intake but treated mice had reduced fasting glycemia and insulin levels.
    CPAG-1 decreased Rev-Erbα protein in BAT of CPAG-1-treated mice.
    CPAG-1 also significantly increased labile heme in the nucleus of brown adipocytes from CPAG-1-treated mice within 4 days of treatment.

    Physicochemical Properties

    M.Wt 326.44
    Formula C20H26N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-butyramido-4-methyl-N-(naphthalen-2-yl)pentanamide

    References

    1. Andrea Galmozzi, et al. Nature. 2019 Dec;576(7785):138-142.

    2. Christopher G Parker, et al. Cell. 2017 Jan 26;168(3):527-541.e29.

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