CPD-2828 | IRE1α PROTAC | Probechem Biochemicals

Chemical Structure : CPD-2828

Catalog No.: PC-25907Not For Human Use, Lab Use Only.

CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM.

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Biological Activity

CPD-2828 is the first PROTAC degrader of IRE1α with DC50 of 0.43 uM in HEK293T cell, exhibits CRBN binding IC50 of 0.65 uM.

M.Wt	531.57
Formula	C29H29N3O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(4-(4-((2,6-dioxopiperidin-3-yl)amino)phenyl)piperidin-1-yl)-2-oxoethyl)-7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde

1. Zerfas BL, et al. RSC Med Chem. 2025 Mar 18. doi: 10.1039/d5md00028a.