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Chemical Structure : CPK20
Catalog No.: PC-22388Not For Human Use, Lab Use Only.
CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.
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CPK20 is a potent, selective inhibitor / blocker of potassium (K+) channel KCNT1 (KNa1.1, Slo2.2, SLACK) with IC50 of 6.4 uM in fluorescence-based assay FluxOR.
CPK20 (10 uM) blocked KCNT1 currents almost completely.
CPK20 is devoid of hERG-blocking activity.
CPK20 could block preferentially KCNT1 vs KCNT2 channels, and to exert a potent blocking effect over clinically-relevant pathogenic KCNT1 variants, thus revealing its potential as target therapy for patients affected by KCNT1-related epilepsies.
| M.Wt | 506.51 | |
| Formula | C23H24F6N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nunzio Iraci, et al. Journal of Medicinal Chemistry, May 23, 2024.
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