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Chemical Structure : CPL500036
Catalog No.: PC-72597Not For Human Use, Lab Use Only.
CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.
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CPL500036 (CPL-500036) is a highly potent, selective and orally bioavailable PDE10A inhibitor with IC50 of 35 nM.
CPL500036 is highly selective for PDE10A over other PDEs and common off-targets.
CPL500036 effectively penetrates the brain where increases cAMP/cGMP levels and phosphorylates effector proteins like AMPA subunits.
CPL500036 reduced sensorimotor deficits in 6-OHDA-lesioned rats.
Acute and chronic CPL500036 did not reduce effects of L-DOPA in sensorimotor tests.
Chronic CPL500036 treatment did not decrease L-DOPA-induced contralateral rotation.
| M.Wt | 341.378 | |
| Formula | C19H15N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tomasz Lenda, et al. Eur J Pharmacol. 2021 Nov 5;910:174460.
2. Moszczyński-Pętkowski R, et al. Eur J Med Chem. 2018 Jul 15;155:96-116.
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