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Chemical Structure : CPTH2
CAS No.: 357649-93-5
Catalog No.: PC-35322Not For Human Use, Lab Use Only.
CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.
CPTH2 increases E1A CR3 transactivation of human adenovirus through inhibition of HAT GCN5.
CPTH2 also reduces virus yield during infection.
CPTH2 induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.
| M.Wt | 291.797 | |
| Formula | C14H14ClN3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-N'-cyclopentylidene-hydrazine |
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1. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.
2. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86.
3. Cocco E, et al. Clin Epigenetics. 2018 Apr 4;10:44.
4. Ablack JN, et al. J Virol. 2012 Aug;86(15):8198-209.
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