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CPTH2

Chemical Structure : CPTH2

CAS No.: 357649-93-5

CPTH2 (GCN5 inhibitor CPTH2, CPTH-2)

Catalog No.: PC-35322Not For Human Use, Lab Use Only.

CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.

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Biological Activity

CPTH2 is a specific histone acetyltransferase inhibitor modulating Gcn5 network in vitro and in vivo, inhibits H3 acetylation and induces cell-cycle perturbation and apoptosis in U-937 cells.
CPTH2 increases E1A CR3 transactivation of human adenovirus through inhibition of HAT GCN5.
CPTH2 also reduces virus yield during infection.
CPTH2 induces apoptosis and decreases the invasiveness of a ccRCC cell line through the inhibition of KAT3B.

Physicochemical Properties

M.Wt 291.797
Formula C14H14ClN3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[4-(4-Chloro-phenyl)-thiazol-2-yl]-N'-cyclopentylidene-hydrazine

References

1. Chimenti F, et al. J Med Chem. 2009 Jan 22;52(2):530-6.

2. Trisciuoglio D, et al. Clin Cancer Res. 2012 Jan 15;18(2):475-86.

3. Cocco E, et al. Clin Epigenetics. 2018 Apr 4;10:44.

4. Ablack JN, et al. J Virol. 2012 Aug;86(15):8198-209.

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