Catalog No.: PC-62450Not For Human Use, Lab Use Only.
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.
CPYPP is a small-molecule inhibitor of the Rac activator DOCK2 with IC50 of 22.8 uM (DOCK2DHR-2-mediated Rac GEF activity), inhibits DOCK2-Rac1 interaction.
CPYPP binds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro.
CPYPP blocks both chemokine receptor- and antigen receptor-mediated Rac activation in lymphocytes, resulting in marked reduction of chemotactic response and T cell activation.
