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CQ80

Chemical Structure : CQ80

CAS No.: 3034207-17-2

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CQ80 (CARD8 activator CQ80)

Catalog No.: PC-23105Not For Human Use, Lab Use Only.

CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome.
CQ80 induces CASP1-dependent cell death in MV4;11 cells with IC50s of 0.27 and 0.45 μM, respectively.
CQ80 is more effective inflammasome activator than CQ31. CQ80 activates the CARD8 inflammasome in both cancer cell lines and normal primary cells.
CQ80 does not activate the human or rodent NLRP1 inflammasomes.
CQ80 disrupts the CARD8-DPP9 ternary complex.

Physicochemical Properties

M.Wt 385.51
Formula C19H35N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-L-prolyl-L-leucinate

References

1. Qifeng Chen, et al. J Med Chem. 2023 Feb 23;66(4):2589-2607.

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