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Chemical Structure : CRANAD-2
CAS No.: 1193447-34-5
Catalog No.: PC-38441Not For Human Use, Lab Use Only.
CRANAD-2 is a blood-brain barrier penetrant, near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift, for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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CRANAD-2 is a blood-brain barrier penetrant, near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift, for the detection of amyloid-β (Aβ) deposits in vitro and in vivo.
CRANAD 2 directly binds to amyloid-β (Aβ) plaques in vitro and APP-PS1 transgenic mice.
CRANAD 2 exhibits a 70-fold increase in fluorescence intensity, a blue shift from 805 to 715 nm, and a large increase in quantum yield.
| M.Wt | 410.3 | |
| Formula | C23H25BF2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-κO3,κO5]difluoroboron |
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1. Chongzhao Ran, et al. J Am Chem Soc. 2009 Oct 28;131(42):15257-61.
2. Chongzhao Ran, et al. PLoS One. 2011 Apr 29;6(4):e19362.
3. Torra J, et al. Chemistry. 2022 Apr 1;28(19):e202200026.
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