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CRD733

Chemical Structure : CRD733

CAS No.: 917089-10-2

CRD733 (ASP4901)

Catalog No.: PC-49573Not For Human Use, Lab Use Only.

CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor.
    CRD-733 reverses TAC-induced left ventricular (LV) hypertrophy in vivo.
    CRD-733 reverses TAC-induced left ventricular dysfunction in mice.
    CRD-733 does not reverse TAC-induced left ventricular (LV) cardiac fibrosis, but attenuates fibrotic gene expression, increases plasma cGMP levels.

    Physicochemical Properties

    M.Wt 369.216
    Formula C15H10Cl2N2O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3,4-dichlorobenzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid

    References

    1. Daniel A Richards, et al. Circ Heart Fail. 2021 Jan;14(1):e007300.

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