Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-NF-κB Pathway-NF-κB-CRL1101
CRL1101

Chemical Structure : CRL1101

CAS No.: 328010-30-6

Add to Favorites

CRL1101 (CRL-1101)

Catalog No.: PC-47045Not For Human Use, Lab Use Only.

CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.
    CRL1101 (15 uM) can sequester RelA in the cytoplasm in TNBC cell lines, MDA-MB-231 and MDA-MB-468.
    CRL1101 significantly inhibited cell proliferation with an inhibition constant of 15 uM in MDA-MB-231 and MDA-MB-468 cells.
    CRL1101 (25 mg/kg/day, i.p.) inhibits tumor growth in TNBC xenograft model.

    Physicochemical Properties

    M.Wt 332.346
    Formula C13H17FN2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-((4-fluoro-3-nitrophenyl)sulfonyl)propyl)morpholine

    References

    1. Kanzaki H, et al. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: