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CRL1101

Chemical Structure : CRL1101

CAS No.: 328010-30-6

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CRL1101 (CRL-1101)

Catalog No.: PC-47045Not For Human Use, Lab Use Only.

CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.
    CRL1101 (15 uM) can sequester RelA in the cytoplasm in TNBC cell lines, MDA-MB-231 and MDA-MB-468.
    CRL1101 significantly inhibited cell proliferation with an inhibition constant of 15 uM in MDA-MB-231 and MDA-MB-468 cells.
    CRL1101 (25 mg/kg/day, i.p.) inhibits tumor growth in TNBC xenograft model.

    Physicochemical Properties

    M.Wt 332.346
    Formula C13H17FN2O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-((4-fluoro-3-nitrophenyl)sulfonyl)propyl)morpholine

    References

    1. Kanzaki H, et al. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430.

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