Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : CRL1101
Catalog No.: PC-47045Not For Human Use, Lab Use Only.
CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.
CRL1101 (15 uM) can sequester RelA in the cytoplasm in TNBC cell lines, MDA-MB-231 and MDA-MB-468.
CRL1101 significantly inhibited cell proliferation with an inhibition constant of 15 uM in MDA-MB-231 and MDA-MB-468 cells.
CRL1101 (25 mg/kg/day, i.p.) inhibits tumor growth in TNBC xenograft model.
| M.Wt | 332.346 | |
| Formula | C13H17FN2O5S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kanzaki H, et al. Breast Cancer (Dove Med Press). 2021 Jul 5;13:419-430.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
