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CRS3123

Chemical Structure : CRS3123

CAS No.: 1013915-71-3

CRS3123 (CRS-3123, REP3123)

Catalog No.: PC-61436Not For Human Use, Lab Use Only.

CRS3123 (REP 3123) is a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases (MetRS) in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).

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Biological Activity

CRS3123 (REP 3123) is a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases (MetRS) in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
CRS3123 inhibits de novo toxin production in high cell density, stationary phase cultures of C. difficile at 1 mg/L.
CRS3123 demonstrates efficacy in the hamster model of CDI and is superior to vancomycin 0.5 mg/kg in CDI model.

Physicochemical Properties

M.Wt 515.264
Formula C19H21Br2N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((3-(((R)-6,8-dibromochroman-4-yl)amino)propyl)amino)-3a,7a-dihydrothieno[3,2-b]pyridin-7(4H)-one

References

1. Citron DM, et al. J Antimicrob Chemother. 2009 May;63(5):972-6.

2. Ochsner UA, et al. J Antimicrob Chemother. 2009 May;63(5):964-71.

3. Critchley IA, et al. J Antimicrob Chemother. 2009 May;63(5):954-63.

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