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CS-0777

Chemical Structure : CS-0777

CAS No.: 827344-05-8

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CS-0777 (CS 0777;CS0777)

Catalog No.: PC-61014Not For Human Use, Lab Use Only.

CS-0777 is a potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CS-0777 is a potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3.
    CS-0777 significantly decreases lymphocyte counts at doses of 0.1 and 1 mg/kg in rats, demonstrates potential benefits in the treatment of autoimmune diseases.

    Physicochemical Properties

    M.Wt 342.483
    Formula C21H30N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(5-(3-amino-4-hydroxy-3-methylbutyl)-1-methyl-1H-pyrrol-2-yl)-4-(p-tolyl)butan-1-one

    References

    1. Nishi T, et al. ACS Med Chem Lett. 2011 Mar 2;2(5):368-72.

    2. Yonesu K, et al. J Biol Chem. 2011 Jul 15;286(28):24765-75.

    3. Moberly JB, et al. J Neuroimmunol. 2012 May 15;246(1-2):100-7.

    4. Inaba S, et al. Xenobiotica. 2015;45(12):1063-80.

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