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Chemical Structure : CS-3150
CAS No.: 1632006-28-0
Catalog No.: PC-60739Not For Human Use, Lab Use Only.
CS-3150 (Esaxerenone, XL-550) is a highly potent, selective and orally active non-steroidal mineralocorticoid receptor antagonist with IC50 of 9.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $528 | In stock | |
| 100 mg | Get quote |
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CS-3150 (Esaxerenone, XL-550) is a highly potent, selective and orally active non-steroidal mineralocorticoid receptor antagonist with IC50 of 9.4 nM.
CS-3150 (Esaxerenone, XL-550) displays >1,000-fold selectivity over other steroid hormone receptors, glucocorticoid receptor, androgen receptor and progesterone receptor.
CS-3150 (Esaxerenone, XL-550) inhibits aldosterone-induced transcriptional activation of human mineralocorticoid receptor with IC50 of 3.7 nM.
CS-3150 (Esaxerenone, XL-550) shows superior potency to that of spironolactone and eplerenone; suppresses aldosterone-induced decrease in urinary Na(+)/K(+) ratio, inhibits blood pressure elevation induced by DOCA/salt-loading in rats.
| M.Wt | 466.475 | |
| Formula | C22H21F3N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(S)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl) phenyl]-5-[2-(trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide |
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1. Arai K, et al. Eur J Pharmacol. 2015 Aug 15;761:226-34.
2. Arai K, et al. Eur J Pharmacol. 2015 Dec 15;769:266-73.
3. Arai K, et al. J Pharmacol Exp Ther. 2016 Sep;358(3):548-57.
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