CS-526 |CAS:313272-12-7 Probechem Biochemicals

Chemical Structure : CS-526

CS-526 (AKU 517;R 105266)

Catalog No.: PC-62893Not For Human Use, Lab Use Only.

CS-526 (AKU 517.

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Biological Activity

CS-526 (AKU 517;R 105266) is a potent, competitive, and reversible acid pump antagonist (potassium-competitive acid blocker) that inhibits H+,K+-ATPase activity with IC50 of 61 nM; inhibits gastric acid secretion in pylorus-ligated rats with ID50 of 0.7 mg/kg (p.o.); inhibits histamine-stimulated gastric acid secretion in Heidenhain pouch dogs, inhibits acute gastric mucosal lesions and has potent antisecretory and antiulcer effects.

Ulcer

Phase 1 Discontinued

Physicochemical Properties

M.Wt	339.414
Formula	C20H22FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine

References

1. Ito K, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):308-17.

2. Ito K, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):163-70.

4. Ito K, et al. Biol Pharm Bull. 2009 Dec;32(12):2010-7.

CS-526 (AKU 517;R 105266)

Biological Activity

Physicochemical Properties

References

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