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CS27109

Chemical Structure : CS27109

CAS No.: 2556627-24-6

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CS27109 (CS 27109)

Catalog No.: PC-20361Not For Human Use, Lab Use Only.

CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.
    CS27109 is about 10-fold more potent to activate THR-β than MGL3196 (Cat. PC-42920).
    CS27109 (15 mg/kg) lessens liver steatosis in HFD rat model, also dose-dependently reduces liver inflammation.
    CS27109 (15 mg/kg) mitigates steatohepatitis and hepatic fibrosis in WD + CCL4 mouse model.

    Physicochemical Properties

    M.Wt 532.11
    Formula C18H8Br2N6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3,5-dibromo-4-((4-oxo-3,4-dihydrophthalazin-1-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

    References

    1. Shengjian Huang, et al. Int J Endocrinol. 2023 Feb 14;2023:4950597.

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