CS640 | CaMK1D inhibitor | Probechem Biochemicals

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Chemical Structure : CS640

CS640 (CS-640)

Catalog No.: PC-72909Not For Human Use, Lab Use Only.

CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.
CS640 prevent Aβ induced tau hyperphosphorylation in culture, but were not able to protect cells from Aβ induced toxicity.
CS640 was able to ablate Aβ induced increased tau phosphorylation at Thr181 in mouse primary neurons.

Physicochemical Properties

M.Wt	397.527
Formula	C21H31N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide

References

1. Paige Grant, et al. Molecules. 2021 Dec 18;26(24):7669.

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CS640 (CS-640)

Biological Activity

Physicochemical Properties

References

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