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CS640

Chemical Structure : CS640

CAS No.: 2388506-83-8

CS640 (CS-640)

Catalog No.: PC-72909Not For Human Use, Lab Use Only.

CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CS640 (CS-640) is a potent, selective CaMK1D inhibitor with nanomolar range at both the enzymatic and cellular levels.
    CS640 prevent Aβ induced tau hyperphosphorylation in culture, but were not able to protect cells from Aβ induced toxicity.
    CS640 was able to ablate Aβ induced increased tau phosphorylation at Thr181 in mouse primary neurons.

    Physicochemical Properties

    M.Wt 397.527
    Formula C21H31N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[(3S)-3-Amino-1-piperidinyl]-4-[[2,6-bis(1-methylethyl)-4-pyridinyl]amino]-5-pyrimidinecarboxamide

    References

    1. Paige Grant, et al. Molecules. 2021 Dec 18;26(24):7669.

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