Chemical Structure : CSB-0914
CAS No.:
CSB-0914
(CSB0914)
Catalog No.: PC-21657Not For Human Use, Lab Use Only.
CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
CSB-0914 is a small molecule NF-κB inhibitor that stably binds to NF-κB-p50 subunit, exhibits significant efficacy in reducing basophil activation assay induced by FcεRI receptors with IC50 of 98.4 nM.
CSB-0914 dose dependently reduces degranulation, effectively reduced the release of TNF-α and IL-2 in DNB-BSA stimulated IgE sensitized RBL-2H3 cells.
CSB-0914 inhibits anti-IgE-FcεRI-stimulated activated basophils with CD63 cell population with IC50 of 98.4 nM.
CSB-0914 inhibits neutrophil elastase activity and reduced neutrophil migration. inhibits phosphorylation of NF-κB and upregulated nrf-2 and HO-1 proteins.
Physicochemical Properties
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M.Wt
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346.39
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Formula
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C20H18N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-N'-benzylidene-2-(4-hydroxy-6-methyl-2-phenylpyrimidin-5-yl)acetohydrazide
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References
1. Mesfer Al Shahrani, et al. J Biomol Struct Dyn. 2023 Dec 21:1-10.
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