CSF1R-IN-22 |CAS:2095849-04-8 Probechem Biochemicals

Chemical Structure : CSF1R-IN-22

CSF1R-IN-22

Catalog No.: PC-62826Not For Human Use, Lab Use Only.

CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit.

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Biological Activity

CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit.
CSF1R-IN-22 has improved metabolic stability and Caco2 permeability.

Physicochemical Properties

M.Wt	479.463
Formula	C25H20F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide

References

1. Ramachandran SA, et al. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.

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CSF1R-IN-22

Biological Activity

Physicochemical Properties

References

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