CSF1R inhibitor 9

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Chemical Structure : CSF1R inhibitor 9

Catalog No.: PC-20762Not For Human Use, Lab Use Only.

CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.
CSF1R inhibitor 9 shows excellent selectivity (Selectivity score: 0.06), evidenced by profiling towards a panel of 468 kinases.
CSF1R inhibitor 9 shows dose-dependent blockade of CSF1-mediated downstream signalling in murine bone marrow-derived macrophages (IC50=106 nM).
CSF1R inhibitor 9 (10 nM) inhibits p-ERK1/2 signalling, inhibits osteoclast differentiation.

Physicochemical Properties

M.Wt	367.45
Formula	C20H25N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	OCCC1=CC=C(C2=NC3=C(N(C)CC4CCOCC4)N=CN=C3N2)C=C1

References

1. Thomas Ihle Aarhus, et al. Eur J Med Chem. 2023 Apr 28;255:115344.

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