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Chemical Structure : CSF1R inhibitor 9
Catalog No.: PC-20762Not For Human Use, Lab Use Only.
CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.
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CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.
CSF1R inhibitor 9 shows excellent selectivity (Selectivity score: 0.06), evidenced by profiling towards a panel of 468 kinases.
CSF1R inhibitor 9 shows dose-dependent blockade of CSF1-mediated downstream signalling in murine bone marrow-derived macrophages (IC50=106 nM).
CSF1R inhibitor 9 (10 nM) inhibits p-ERK1/2 signalling, inhibits osteoclast differentiation.
| M.Wt | 367.45 | |
| Formula | C20H25N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomas Ihle Aarhus, et al. Eur J Med Chem. 2023 Apr 28;255:115344.
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