CSTI-300 (SMP-100)

Chemical Structure : CSTI-300

Catalog No.: PC-47112Not For Human Use, Lab Use Only.

CSTI-300 (SMP-100) is a potent, selective 5-HT3 receptor partial agonist with high affinity for human and rat 5-HT3 receptor (Ki=2.0 nM).

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Biological Activity

CSTI-300 (SMP-100) is a potent, selective 5-HT3 receptor partial agonist with high affinity for human and rat 5-HT3 receptor (Ki=2.0 nM).
CSTI-300 demonstrates over 100-fold greater affinity compared with 5-HT, shows comparable affinity against h5-HT3A, h5-HT3AB, and r5-HT3A receptors.
CSTI-300 demonstrate the potential therapeutic effectiveness as a treatment of symptoms associated with IBS-d and carcinoid syndrome.
CSTI-300 displays a similar binding affinity to ondansetron and 10 times lower affinity than the very high-affinity 5-HT3 receptor antagonist, alosetron.

Physicochemical Properties

M.Wt	296.374
Formula	C17H20N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7-(quinuclidin-3-yl)-2,7,8,9-tetrahydro-6H-azepino[5,4,3-cd]indazol-6-one

References

1. Roberts A, et al. J Pharmacol Exp Ther. 2020 Apr;373(1):122-134.

CSTI-300 (SMP-100)

Biological Activity

Physicochemical Properties

References

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