Catalog No.: PC-35182Not For Human Use, Lab Use Only.
CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM).
CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM).
CTA056 shows selectivity for Itk over other Tec family members; inhibits the phosphorylation of Itk and its effectors including PLC-γ, Akt, and ERK, as well as the decreased secretion of targeted genes such as IL-2 and IFN-γ in treated Jurkat and MOLT-4 cells.
CTA056 also exhibits apoptosis-inducing potential in Jurkat cells.
CTA056 demonstrates cytotoxic effect in xenograft models of T-cell leukemia and lymphoma.
