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CTA095

Chemical Structure : CTA095

CAS No.: 1265823-05-9

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CTA095 (CTA 095;CTA-095)

Catalog No.: PC-35181Not For Human Use, Lab Use Only.

CTA095 (CTA-095) is a potent Etk (BMX) and Src dual inhibitor with IC50 of 60 and 120 nM, respectively, shows no significant inhibition on Btk and Yes at 10 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CTA095 (CTA-095) is a potent Etk (BMX) and Src dual inhibitor with IC50 of 60 and 120 nM, respectively, shows no significant inhibition on Btk and Yes at 10 uM.
    CTA095 induces autophagy and apoptosis, as well as synergistic effects with autophagy modulators in prostate cancer cells.
    CTA095 inhibits the phosphorylation of Etk, Src and the downstream signals Stat3 and Akt in prostate cancer cells.
    CTA095nano inhibits PC3 xenograft tumor growth in vivo.

    Physicochemical Properties

    M.Wt 553.666
    Formula C35H31N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(dibenzo[b,d]furan-2-yl)-7-phenyl-1-(3-(piperidin-1-yl)propyl)-1H-imidazo[4,5-g]quinoxalin-6(5H)-one

    References

    1. Guo W, et al. PLoS One. 2013 Aug 15;8(8):e70910.

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