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Chemical Structure : CTA095
Catalog No.: PC-35181Not For Human Use, Lab Use Only.
CTA095 (CTA-095) is a potent Etk (BMX) and Src dual inhibitor with IC50 of 60 and 120 nM, respectively, shows no significant inhibition on Btk and Yes at 10 uM.
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CTA095 (CTA-095) is a potent Etk (BMX) and Src dual inhibitor with IC50 of 60 and 120 nM, respectively, shows no significant inhibition on Btk and Yes at 10 uM; induces autophagy and apoptosis, as well as synergistic effects with autophagy modulators in prostate cancer cells; inhibits the phosphorylation of Etk, Src and the downstream signals Stat3 and Akt in prostate cancer cells; CTA095nano inhibits PC3 xenograft tumor growth in vivo.
| M.Wt | 553.666 | |
| Formula | C35H31N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guo W, et al. PLoS One. 2013 Aug 15;8(8):e70910.
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